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Publications

Selected Publications

Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Balderas Figueroa G, So RWL, Stuart E, Panchal R, Akrioti EK, Joseph JT, Haji-Ghassemi O, Taoufik E, Akhtar TA, Watts JC, Ryan SD. (2025). G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis. Cell Reports Jan 28; 44(1) 115178. doi: 10.1016/j.celrep.2024.115178

Stykel MG, Ryan SD. (2024). Network Analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease. BBA-Molecular Cell Research. June; 1871(5) 119720. doi: 10.1016/j.bbamcr.2024.119720

Parmasad JLA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, Joselin A, Tomlinson JJ, Schlossmacher MG, Stanford WL, Ma J, Brundin P, Ryan SD, Rousseaux MWC. (2024). Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Nature. April 4; 15, 246. doi: 10.1038/s41419-024-06534-8

Hallam RD*, Buchner-Duby B*, Stykel MG, Coackley CL, Ryan SD. Intracellular accumulation of α-synuclein aggregates promotes S-nitrosylation of MAP1A leading to decreased NMDAR-evoked calcium influx and loss of mature synaptic spines. (2022) J Neurosci. 10.1523/ JNEUROSCI.0074-22.2022.

Stykel MG, Humphries KM, Kamski-Hennekam E, Buchner-Duby B, Ryan T, Coackley CL, Bamm VV, Harauz G, Ryan SD. (2021) a-synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of a-synuclein pathology. Cell Reports. May 11;35(6):109099. doi: 10.1016/j.celrep.2021.109099

Czaniecki C, Ryan T, Stykel MG, Drolet J, Heide J, Hallam R, Wood S, Coackley C, Sherriff K, Bailey CDC and Ryan SD (2019). Axonal pathology in hPSC-based models of Parkinson's Disease results from loss of Nrf2-transcriptional activity at the Map1b gene locus. Proc Natl Acad Sci USA. Jun 24. pii: 201900576. doi: 10.1073/pnas.

Stykel, MG, Humphries K, Kirby MP, Czaniecki C, Wang T, Ryan T, Bamm V and Ryan SD (2018). Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease. The FASEB Journal. Apr 24:fj201700759RR. doi: 10.1096/fj.201700759RR.

Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD (2018) Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. Feb 26;9(1):817. doi: 10.1038/s41467-018-03241-9.

Tu S, Akhtar M, Escorheula RM, Amador-Arjona A, Swarup V, Parker J, Zaremba J, Holland T, Bansal N, Holohan D, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, McKercher S, Ambasudhan R, Wang Y, Geschwind D, Roberts A, Terskikh A, Rissman RA, Masliah E, Lipton S, Nakanishi N. (2017). NitroSynapsin therapy for the mouse MEF2C haplo-insufficiency model of human autism. Nature Communications. Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8.

Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, , Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Masliah E, Yates JR, Nakanishi N, Andreyev A, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA (2013) Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription. CELL, Dec 5:155(6) 1351.

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